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Архив | Том 25, 2020, No. 4.

INFLUENCE OF THE NATURE OF DRUGS ON THE CONFORMATIONAL AND SUPRAMOLECULAR STATES OF SOME POLYMERS USED AS PROLONGATORS OF THE EFFECT OF DRUGS

Вестник Башкирского университета. 2020. Том 25. №4. С. 788-793.
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  • © A. S. Shurshina

    Bashkir State University

    32 Zaki Validi Street, 450076 Ufa, Republic of Bashkortostan, Russia

  • © A. R. Galina

    Bashkir State University

    32 Zaki Validi Street, 450076 Ufa, Republic of Bashkortostan, Russia

  • © M. Yu. Lazdina

    Bashkir State University

    32 Zaki Validi Street, 450076 Ufa, Republic of Bashkortostan, Russia

  • © A. S. Titlova

    Bashkir State University

    32 Zaki Validi Street, 450076 Ufa, Republic of Bashkortostan, Russia

  • © E. I. Kulish

    Bashkir State University

    32 Zaki Validi Street, 450076 Ufa, Republic of Bashkortostan, Russia

The work is devoted to the creation of dosage forms of prolonged action, based on physiologically active polymers - nonionic polyvinyl alcohol and ionic chitosan and sodium salt of succinyl chitosan. Low molecular weight electrolytes cefazolin, lidocaine, and non-electrolyte dioxidine were used as drugs. It was found that in the case of the use of ionic polymers and drugs, which are low molecular weight electrolytes, their addition to polymer solutions in a wide concentration range is accompanied by changes in the conformational and supramolecular state of polymers, which can not affect the interaction of polymers with drugs, and, consequently, and on the ability of polymers to prolong drug release.

Ключевые слова:

  • polyelectrolytes
  • rheology
  • conformational-supramolecular state

ЛИТЕРАТУРА

  1. Chen G. Q., Wu Q. The application of polyhydroxyalkanoates as tissue engineering materials // Biomaterials. 2005. No. 33. Pp. 6565-6578.
  2. Park J., Ye M., Park K. Biodegradable Polymers for Microencapsulation of Drugs // Molecules. 2005. No. 1. Pp. 146-161.
  3. Anurova M. N., Demina N. B., Bakhrushina E. O. Physicochemical and Technical Studies of an Interpolymer Complex of Polymethyacrylic Acid and Polyethylene Glycol as the Base for Creating Matrix Systems // Pharmaceutical Chemistry Journal. 2018. No. 7. Pp. 635-640.
  4. Lowinger M. B., Barrett S. E., Zhang F., Williams R. O. Sustained release drug delivery applications of polyurethanes // Pharmaceutics. 2018. No. 2. P. 55.
  5. Shtilman M. I. Biomaterials are an important area of biomedical technologies // Vestnik RGMU. 2016. No. 5. Pp. 4-15.
  6. Vlakh Ye. G., Zashikhina N. N., Tennikova T. B. Perspektivnyye sistemy dostavki lekarstv na osnove amfifil'nykh polipeptidov // Aktual'nyye voprosy biologicheskoy fiziki i khimii. 2016. No. 2. Pp. 90-94.
  7. Oltarzhevskaya N. D., Krichevskiy G. Ye., Korovina M. A., Gusev I. V. Biopolimery v meditsine. Uspekhi, problemy, budushcheye. Lechebnyye depo-materialy na osnove biopolimera al'ginata natriya. Printsipy sozdaniya i primeneniya (obzor) // Biofarmatsevticheskiy zhurnal. 2017. No. 2. Pp. 3-25.
  8. Ipatova O. M., Torkhovskaya T. I., Medvedeva N. V., Prozorovsky V. N., Ivanova N. D., Shironin A. V., Baranova V. S., Archakov A. I. Bioavailability of oral drugs and the methods for its improvement // Biochemistry (Moscow) Supplement. Series B: Biomedical Chemistry. 2010. No. 1. Pp. 82-94.
  9. Plate N. A., Vasil'yev A. Ye. Fiziologicheski aktivnyye polimery. M.: Khimiya, 1986.
  10. Zhilyakova Ye. T., Popov N. N., Novikova M. Yu., Novikov O. O., Fadeyeva D. A. Izucheniye fiziko-khimicheskikh i tekhnologicheskikh kharakteristik kombinirovannogo prolongatora natriy karboksimetiltselllyulozy i polivinilovogo spirta s tsel'yu sozdaniya prolongirovannykh lekarstvennykh form s zhidkoy dispersionnoy sredoy // Nauchnyye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Meditsina. Farmatsiya. 2011. No. 22-2. Pp. 69-79.
  11. Novikova L. S., Shormanov V. K., Belyayeva G. V., Akhmetzyanova I. N., Belyayeva T. V. Kollagen v farmatsii i meditsine // Farmatsiya. 2011. No. 4. Pp. 52-56.
  12. Ryabtseva A. A., Rakhman Sheikh M. Kh. Some modern antihypertensive drugs for the treatment of ophthalmic hypertension and glaucoma // Clinical Ophthalmology (B-ka BC). 2001. No. 2. Pp.70-73.
  13. Tentsova A. I., Alyushina M. T. Polimery v farmatsii. M.: Meditsina, 1985.
  14. Litmanovich O. E., Marmuzov G. V., Eliseeva E. A., Litmanovich A. A., Papisov I. M. Effect of interaction between polyelectrolyte macromolecules and metal nanoparticles on the formation and properties of a polymer-metal nanocomposite sol // Polymer Science. Series A. 2002. Vol. 44. No. 6. Pp. 609-614.
  15. Baranov V. G., Ambribakhshev D. KH., Agranova S. A., Frenkel' S. YA. Kontsentratsionnaya zavisimost' fundamental'nogo vremeni relaksatsii makromolekul // Vysokomolekulyarnyye soyedineniya. Seriya B. 1988. Vol. 30. No 5. Pp. 384.
  16. Bazunova M. V., Shurshina A. S., Chernova V. V., Kulish E. I. A rheological study of molecular and supramolecular organization of chitosan succinamide in a mixed water-etanol solvent // Russian Journal of Physical Chemistry B. 2016. Vol. 10. No. 6. Pp. 1014-1021.
  17. Malkin A. Ya., Isayev A. I. Reologiya: kontseptsii, metody, prilozheniya. Spb.: Professiya, 2007.
  18. Schramm G. A. Practical Approach to Rheology and Rheometry. Karlsruhe, Federal Republic of Germany: Gebrueder HAAKE GmbH, 1998.
  19. Vinogradov G. V., Malkin A. YA. Reologiya polimerov. M.: Khimiya, 1977.
  20. Ferry J. D. Viscoelastic Properties of Polymers. NewYork: Wiley, 1980.
  21. Doy M., Edvards S. Dinamicheskaya teoriya polimerov. M.: Mir, 1998.
  22. De Zhen P. Idei skeylinga v fizike polimerov. M.: Mir, 1982.
  23. Litmanovich E. A., Syaduk G. V., Lysenko E. A., Zezin A. B., Kabanov A. V., Kabanov V. A. Effect of concentration regime on rheological properties of sodium polymethacrylate and its complexes with polystyrene-poly(n-ethyl-4- vinylpyridinium bromide) block copolymer in aqueous salt solution // Polymer Science. Series A. 2006. No. 9. Pp. 997-1003.
  24. Dobrynin A. V., Rubinstein M., Colby R. H. Scaling theory of polyelectrolyte solutions // Macromolecules. 1995. No. 6. Pp. 1859-1871.
  25. Litmanovich E. A., Orleneva A. P., Korolev B. A., Kasaikin V. A., Kulichikhin V. G. Dynamics of polymer chain in aqueous and salt-containing aqueous solutions of poly(dimethyl diallylammonium chloride) // Polymer Science. А. 2000. No. 6. Pp. 689-693.

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